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Major affective disorder 2; MAFD2

Disease ID:608
Name:Major affective disorder 2; MAFD2
Associated with:1 target
Bipolar affective disorder
Database Links
OMIM: 309200


Comments:  A role for GPR50 in mental disorders, such as Alzheimer's and schizophrenia, has been postulated .
References:  1-2
Mutations:  GPR50 is associated with 1 mutation. Click here for details


No ligand related data available for Major affective disorder 2; MAFD2


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1. Gerwins P, Nordstedt C, Fredholm BB. (1990) Characterization of adenosine A1 receptors in intact DDT1 MF-2 smooth muscle cells. Mol. Pharmacol., 38 (5): 660-6. [PMID:2172773]

2. Grünewald E, Kinnell HL, Porteous DJ, Thomson PA. (2009) GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth. Mol. Cell. Neurosci., 42 (4): 363-71. [PMID:19699797]

3. Macintyre DJ, McGhee KA, Maclean AW, Afzal M, Briffa K, Henry B, Thomson PA, Muir WJ, Blackwood DH. (2010) Association of GPR50, an X-linked orphan G protein-coupled receptor, and affective disorder in an independent sample of the Scottish population. Neurosci. Lett., 475 (3): 169-73. [PMID:20371266]