Spermatogenic failure 7; SPGF7
GtoPdb Disease Summaries
This section gives an overview of the disease, and where available shows the following:
- Synonyms: Shows known synonyms for the disease.
- Description: Gives a basic description/definition of the disease.
- Database Link: External links to the same disease at the Disease Ontology, OMIM or Orphanet sites.
- Immunopharmacology comments: General comments about the target's role in immunopharmacology, provided by GtoImmuPdb curators.
- Associated with: Counts are displayed for the total targets the disease is associated with in GtoPdb. The counts of targets and ligands of immunological relevance associated to the disease are also shown.
More information can be found in the help pages.
✖| Disease ID: | 872 | |
| Name: | Spermatogenic failure 7; SPGF7 | |
| Associated with: | 1 target | |
| Synonyms |
| Non-syndromic male infertility due to sperm motility disorder |
| Database Links |
|
OMIM:
612997 Orphanet: ORPHA276234 |
Targets
GtoPdb Disease Summaries - Targets
Click on the target name to link to its detailed view page
Where available, information is display on the role of the target in the disease; drugs which target the disease and their therapeutic use and side-effects.
If there is mutation data curated in GtoPdb this is indicated, with a link back to the appropriate section on the target detailed view page
Immuno ligand interactions - If available, a table of immuno-relevant ligands is shown. These ligands have been curated as having an association to the disease and possess interaction data with the target in GtoPdb. The approval status of the ligand is shown, along with curator comments and an indication of whether the target is considered the primary target of the ligand.
More information can be found in the help pages.
✖| CatSper1 | |
| Role: | The frameshift caused by this 5 bp insertion substitutes a methionine at Asp317 and introduces 18 novel residues before a premature stop codon (asp317metfsX18). In the absence of nonsense-mediated decay, the predicted product would be a truncated 335-residue protein. CatSper1 is one of four alpha subunits of the sperm-specific CatSper calcium channel known to be essential for normal male fertility in mice. The mutation suggests that CATSPER1 is also essential for normal male fertility in humans (see OMIM table 606389.0002). Insertion of a thymine at nucleotide 539 in exon 1 of the CATSPER1 gene introduces 8 novel amino acids followed by premature termination codon into the CatSper1 protein (lys180lysfsX8). If the aberrant transcript is not subject to nonsense-mediated decay, a severely truncated 188 aa protein would be translated. CatSper1 is one of four alpha subunits of the sperm-specific CatSper calcium channel known to be essential for normal male fertility in mice. The mutation suggests that CATSPER1 is also essential for normal male fertility in humans (see OMIM table 606389.0001) |
| Comments: | The frameshift mutation was found in a male from a consanguineous Iranian family with nonsyndromic infertility characterised by sperm defects and reduced fertility. The thiamine insertion mutation was found in 2 brothers from a consanguneous Iranian family with nonsyndromic male infertilty characterised by sperm defects and reduced fertility. |
| References: | 1 |
| Mutations: | CatSper1 is associated with 2 mutation. Click here for details  |
Ligands
GtoPdb Disease Summaries - Ligands
Click ligand name to view ligand summary page
- Approved: If the ligand is an approved drug this is indicated, along with approval bodies.
- Immuno: Immuno icon indicates the ligand is immuno-relevant
Click the arrow in the final column to expand comments
- Immuno Disease Comments: Curatorial comments specifically added as part of GtoImmuPdb. They give more information on the association between the ligand and disease in the context of immunopharmacology.
- Clinical Use: General clinical comments relating to the ligand and may not necessarily be specific to the disease in question. With hyperlink to more details on the ligand summary pages.
- Bioactivty Comments: Curatorial comments specifically about the compounds biological activity - with hyperlink to more details on the ligand summary pages.
More information can be found in the help pages.
✖No ligand related data available for Spermatogenic failure 7; SPGF7
