The family of SLC55 mitochondrial transporters appear to regulate ion fluxes and to maintain tubular networks.

* Key recommended reading is highlighted with an asterisk

Durigon R, Mitchell AL, Jones AW, Manole A, Mennuni M, Hirst EM, Houlden H, Maragni G, Lattante S, Doronzio PN et al.. (2018) LETM1 couples mitochondrial DNA metabolism and nutrient preference. EMBO Mol Med, 10 (9). [PMID:30012579]

Huang E, Qu D, Huang T, Rizzi N, Boonying W, Krolak D, Ciana P, Woulfe J, Klein C, Slack RS et al.. (2017) PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress. Nat Commun, 8 (1): 1399. [PMID:29123128]

Yang Z, Ni W, Cui C, Qi W, Piao L, Xuan Y. (2018) Identification of LETM1 as a marker of cancer stem-like cells and predictor of poor prognosis in esophageal squamous cell carcinoma. Hum Pathol, 81: 148-156. [PMID:30031102]

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2. Endele S, Fuhry M, Pak SJ, Zabel BU, Winterpacht A. (1999) LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients. Genomics, 60 (2): 218-25. [PMID:10486213]

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6. Shao J, Fu Z, Ji Y, Guan X, Guo S, Ding Z, Yang X, Cong Y, Shen Y. (2016) Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca²⁺/H⁺ antiporter. Sci Rep, 6: 34174. [PMID:27669901]

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