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SLC56 Sideroflexins C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

3028
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sideroflexin 1 / SLC56A1 C Show summary »


Target Id 3028
Nomenclature sideroflexin 1
Systematic nomenclature SLC56A1
Previous and unofficial names FLJ12876
Genes SFXN1 (Hs), Sfxn1 (Mm), Sfxn1 (Rn)
Ensembl ID ENSG00000164466 (Hs), ENSMUSG00000021474 (Mm), ENSRNOG00000018279 (Rn)
UniProtKB AC Q9H9B4 (Hs), Q99JR1 (Mm)
Comment Sideroflexin 1 (SFXN1/SLC56A1) was probably falsely identified as a tricarboxylate carrier in the 1993 article by Azzi et al. [1], as discussed several years later in [2]. SFXN1 likely transports pyridoxin or another heme precursor or the 5'-aminolevulinate synthase 2 (ALAS2; P22557) cofactor [2,4]. SFXN1 has recently been suggested to be a mitochondrial serine transporter [3]. It is mainly expressed in adult kidney and liver (mouse) [2].

sideroflexin 2 / SLC56A2 C Show summary »

sideroflexin 3 / SLC56A3 C Show summary »

sideroflexin 4 / SLC56A4 C Show summary »

sideroflexin 5 / SLC56A5 C Show summary »

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References

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How to cite this family page

Database page citation:

SLC56 Sideroflexins. Accessed on 17/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1008.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.