SLC59 Sodium-dependent lysophosphatidylcholine symporter family | Transporters

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SLC59 Sodium-dependent lysophosphatidylcholine symporter family

SLC59 Sodium-dependent lysophosphatidylcholine symporter family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

major facilitator superfamily domain containing 2A / SLC59A1 C Show summary »« Hide summary

Target Id

3041

Nomenclature

major facilitator superfamily domain containing 2A

Systematic nomenclature

SLC59A1

Previous and unofficial names

MFSD2 | NLS1

Genes

MFSD2A (Hs), Mfsd2a (Mm), Mfsd2a (Rn)

Ensembl ID

ENSG00000168389 (Hs), ENSMUSG00000028655 (Mm), ENSRNOG00000014008 (Rn)

UniProtKB AC

Q8NA29 (Hs), Q9DA75 (Mm)

Transport type

Co-transporter: LPC:Na⁺, uptake

Substrates

LPC (lysophosphatidylcholine) form of DHA (docosahexaenoic acid) [3]

Comment

MFSD2B/SLC59A has been suggested to be a sphingosine 1-phosphate transporter in erythropoietic cells [2]. It is expressed in brain, intestine, kidney, liver, lung, mammary gland, and prostate [1]; relatively low expression in BAT (brown adipose tissue), but upregulated during cold-induced thermogenesis [1]. Subcellular locations: plasma membrane [4] and ER [1].

major facilitator superfamily domain containing 2B / SLC59A2 C Show summary »« Hide summary

Target Id	3042
Nomenclature	major facilitator superfamily domain containing 2B
Systematic nomenclature	SLC59A2
Genes	MFSD2B (Hs), Mfsd2b (Mm), Mfsd2b (Rn)
Ensembl ID	ENSG00000205639 (Hs), ENSMUSG00000037336 (Mm), ENSRNOG00000023508 (Rn)
UniProtKB AC	A6NFX1 (Hs)
Comment	Expressed in the spleen, lung, testis and subcellularly in the ER [1].

Harel T, Quek DQY, Wong BH, Cazenave-Gassiot A, Wenk MR, Fan H, Berger I, Shmueli D, Shaag A, Silver DL et al.. (2018) Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination. Neurogenetics, 19 (4): 227-235. [PMID:30043326]

Zhang W, Chen R, Yang T, Xu N, Chen J, Gao Y, Stetler RA. (2018) Fatty acid transporting proteins: Roles in brain development, aging, and stroke. Prostaglandins Leukot. Essent. Fatty Acids, 136: 35-45. [PMID:28457600]

References

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1. Angers M, Uldry M, Kong D, Gimble JM, Jetten AM. (2008) Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem. J., 416 (3): 347-55. [PMID:18694395]

2. Kobayashi N, Kawasaki-Nishi S, Otsuka M, Hisano Y, Yamaguchi A, Nishi T. (2018) MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells. Sci Rep, 8 (1): 4969. [PMID:29563527]

3. Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, Wenk MR, Goh EL, Silver DL. (2014) Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature, 509 (7501): 503-6. [PMID:24828044]

4. Wang JZ, Xiao N, Zhang YZ, Zhao CX, Guo XH, Lu LM. (2016) Mfsd2a-based pharmacological strategies for drug delivery across the blood-brain barrier. Pharmacol. Res., 104: 124-31. [PMID:26747400]

How to cite this family page

Database page citation:

SLC59 Sodium-dependent lysophosphatidylcholine symporter family. Accessed on 23/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1011.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.

SLC59 Sodium-dependent lysophosphatidylcholine symporter family C

Transporters

Further reading

References

How to cite this family page