SLC59 Sodium-dependent lysophosphatidylcholine symporter family | Transporters

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SLC superfamily of solute carriers
SLC59 Sodium-dependent lysophosphatidylcholine symporter family

SLC59 Sodium-dependent lysophosphatidylcholine symporter family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

MFSD2 lysolipid transporter A, lysophospholipid / SLC59A1 C Show summary »« Hide summary

Target Id

3041

Nomenclature

MFSD2 lysolipid transporter A, lysophospholipid

Systematic nomenclature

SLC59A1

Previous and unofficial names

MFSD2 lysolipid transporter A | major facilitator superfamily domain containing 2A | MFSD2 | NLS1

Genes

MFSD2A (Hs), Mfsd2a (Mm), Mfsd2a (Rn)

Ensembl ID

ENSG00000168389 (Hs), ENSMUSG00000028655 (Mm), ENSRNOG00000014008 (Rn)

UniProtKB AC

Q8NA29 (Hs), Q9DA75 (Mm)

RESOLUTE

MFSD2A (Hs)

Transport type

Co-transporter: LPC:Na⁺, uptake

Substrates

LPC (lysophosphatidylcholine) form of DHA (docosahexaenoic acid) [3]

Comment

MFSD2/SLC59A1 has been suggested to be a sphingosine 1-phosphate transporter in erythropoietic cells [2]. It is expressed in brain, intestine, kidney, liver, lung, mammary gland, and prostate [1]; relatively low expression in BAT (brown adipose tissue), but upregulated during cold-induced thermogenesis [1]. Subcellular locations: plasma membrane [4] and ER [1].

MFSD2 lysolipid transporter B, sphingolipid / SLC59A2 C Show summary »« Hide summary

Target Id	3042
Nomenclature	MFSD2 lysolipid transporter B, sphingolipid
Systematic nomenclature	SLC59A2
Previous and unofficial names	major facilitator superfamily domain containing 2B \| MFSD2 lysolipid transporter B
Genes	MFSD2B (Hs), Mfsd2b (Mm), Mfsd2b (Rn)
Ensembl ID	ENSG00000205639 (Hs), ENSMUSG00000037336 (Mm), ENSRNOG00000023508 (Rn)
UniProtKB AC	A6NFX1 (Hs)
RESOLUTE	MFSD2B (Hs)
Comment	Expressed in the spleen, lung, testis and subcellularly in the ER [1].

Harel T, Quek DQY, Wong BH, Cazenave-Gassiot A, Wenk MR, Fan H, Berger I, Shmueli D, Shaag A, Silver DL et al.. (2018) Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination. Neurogenetics, 19 (4): 227-235. [PMID:30043326]

Zhang W, Chen R, Yang T, Xu N, Chen J, Gao Y, Stetler RA. (2018) Fatty acid transporting proteins: Roles in brain development, aging, and stroke. Prostaglandins Leukot Essent Fatty Acids, 136: 35-45. [PMID:28457600]

References

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1. Angers M, Uldry M, Kong D, Gimble JM, Jetten AM. (2008) Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem J, 416 (3): 347-55. [PMID:18694395]

2. Kobayashi N, Kawasaki-Nishi S, Otsuka M, Hisano Y, Yamaguchi A, Nishi T. (2018) MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells. Sci Rep, 8 (1): 4969. [PMID:29563527]

3. Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, Wenk MR, Goh EL, Silver DL. (2014) Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature, 509 (7501): 503-6. [PMID:24828044]

4. Wang JZ, Xiao N, Zhang YZ, Zhao CX, Guo XH, Lu LM. (2016) Mfsd2a-based pharmacological strategies for drug delivery across the blood-brain barrier. Pharmacol Res, 104: 124-31. [PMID:26747400]

How to cite this family page

Database page citation:

SLC59 Sodium-dependent lysophosphatidylcholine symporter family. Accessed on 12/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1011.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.

SLC59 Sodium-dependent lysophosphatidylcholine symporter family C

Transporters

Further reading

References

How to cite this family page