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SLC59 Sodium-dependent lysophosphatidylcholine symporter family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

3041
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MFSD2 lysolipid transporter A, lysophospholipid / SLC59A1 C Show summary »


Target Id 3041
Nomenclature MFSD2 lysolipid transporter A, lysophospholipid
Systematic nomenclature SLC59A1
Previous and unofficial names MFSD2 lysolipid transporter A | major facilitator superfamily domain containing 2A | MFSD2 | NLS1
Genes MFSD2A (Hs), Mfsd2a (Mm), Mfsd2a (Rn)
Ensembl ID ENSG00000168389 (Hs), ENSMUSG00000028655 (Mm), ENSRNOG00000014008 (Rn)
UniProtKB AC Q8NA29 (Hs), Q9DA75 (Mm)
RESOLUTE MFSD2A (Hs)
Transport type Co-transporter: LPC:Na+, uptake
Substrates
LPC (lysophosphatidylcholine) form of DHA (docosahexaenoic acid) [3]
Comment MFSD2/SLC59A1 has been suggested to be a sphingosine 1-phosphate transporter in erythropoietic cells [2]. It is expressed in brain, intestine, kidney, liver, lung, mammary gland, and prostate [1]; relatively low expression in BAT (brown adipose tissue), but upregulated during cold-induced thermogenesis [1]. Subcellular locations: plasma membrane [4] and ER [1].

MFSD2 lysolipid transporter B, sphingolipid / SLC59A2 C Show summary »

Further reading

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References

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How to cite this family page

Database page citation:

SLC59 Sodium-dependent lysophosphatidylcholine symporter family. Accessed on 03/03/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1011.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.