SLC63 Sphingosine phosphate transporters | Transporters

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SLC superfamily of solute carriers
SLC63 Sphingosine phosphate transporters

SLC63 Sphingosine phosphate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLC63 family of transporters has roles inside the cell (SLC63A1/SPNS1) or on the cell surface (SLC63A2/SPNS2) in sphingolipid transport.

Transporters

SPNS lysolipid transporter 1, lysophospholipid / SLC63A1 C Show summary »« Hide summary

Target Id	3047
Nomenclature	SPNS lysolipid transporter 1, lysophospholipid
Systematic nomenclature	SLC63A1
Previous and unofficial names	sphingolipid transporter 1 (putative) \| spinster homolog 1 \| sphingolipid transporter 1 \| hSpin1 \| SPIN1 \| spinster homolog 1 (Drosophila)
Genes	SPNS1 (Hs), Spns1 (Mm), Spns1 (Rn)
Ensembl ID	ENSG00000169682 (Hs), ENSMUSG00000030741 (Mm), ENSRNOG00000017621 (Rn)
UniProtKB AC	Q9H2V7 (Hs), Q8R0G7 (Mm), Q2YDU8 (Rn)
RESOLUTE	SPNS1 (Hs)
Comment	Expressed in mitochondria [8].

SPNS lysolipid transporter 2, sphingosine-1-phosphate / SLC63A2 Show summary »« Hide summary

Target Id

3048

Nomenclature

SPNS lysolipid transporter 2, sphingosine-1-phosphate

Systematic nomenclature

SLC63A2

Previous and unofficial names

sphingolipid transporter 2 | spinster homolog 2 | SPNS lysolipid transporter 2

Genes

SPNS2 (Hs), Spns2 (Mm), Spns2 (Rn)

Ensembl ID

ENSG00000183018 (Hs), ENSMUSG00000040447 (Mm), ENSRNOG00000057040 (Rn)

UniProtKB AC

Q8IVW8 (Hs), Q91VM4 (Mm)

RESOLUTE

SPNS2 (Hs)

Substrates

Phosphorylated fingolimod (FTY720-P) [5]

Phosphorylated sphingolipids [7]

Sphingosine-1-phosphate (S1P), dihydrosphingosine-1-phosphate (DH-S1P), phyto-S1P, C17-S1P [5]

Inhibitors

SLF80821178 pIC₅₀ 7.3 [3]

SLB1122168 pIC₅₀ 7.0 [1]

SLF1081851 pIC₅₀ 5.7 [4]

Comment

Expressed in lung and placenta, and is abundant in many other tissues [5]. Exports S1P to modulate lipid signaling pathways [2].

SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative) / SLC63A3 Show summary »« Hide summary

Target Id	3049
Nomenclature	SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)
Systematic nomenclature	SLC63A3
Previous and unofficial names	sphingolipid transporter 3 (putative) \| spinster homolog 3 \| spinster homolog 3 (Drosophila)
Genes	SPNS3 (Hs), Spns3 (Mm), Spns3 (Rn)
Ensembl ID	ENSG00000182557 (Hs), ENSMUSG00000020798 (Mm), ENSRNOG00000015873 (Rn)
UniProtKB AC	Q6ZMD2 (Hs), Q9D232 (Mm)
RESOLUTE	SPNS3 (Hs)
Comment	Highly expressed in rat coronal brain sections of the olfactory bulb and frontal cortex; moderately expressed in other coronal sections and in thymus, kidney, and spleen (qRT-PCR detection of mRNA) [6]

References

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1. Burgio AL, Shrader CW, Kharel Y, Huang T, Salamoun JM, Lynch KR, Santos WL. (2023) 2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2). J Med Chem, 66 (8): 5873-5891. [PMID:37010497]

2. Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH. (2023) Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate. Cell, 186 (12): 2644-2655.e16. [PMID:37224812]

3. Foster DJ, Dunnavant K, Shrader CW, LoPresti M, Seay S, Kharel Y, Brown AM, Huang T, Lynch KR, Santos WL. (2024) Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors. J Med Chem,. DOI: 10.1021/acs.jmedchem.4c00879

4. Fritzemeier R, Foster D, Peralta A, Payette M, Kharel Y, Huang T, Lynch KR, Santos WL. (2022) Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors. J Med Chem, 65 (11): 7656-7681. [PMID:35609189]

5. Hisano Y, Kobayashi N, Kawahara A, Yamaguchi A, Nishi T. (2011) The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. J Biol Chem, 286 (3): 1758-66. [PMID:21084291]

6. Jacobsson JA, Haitina T, Lindblom J, Fredriksson R. (2007) Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Genomics, 90 (5): 595-609. [PMID:17714910]

7. Kawahara A, Nishi T, Hisano Y, Fukui H, Yamaguchi A, Mochizuki N. (2009) The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. Science, 323 (5913): 524-7. [PMID:19074308]

8. Yanagisawa H, Miyashita T, Nakano Y, Yamamoto D. (2003) HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death. Cell Death Differ, 10 (7): 798-807. [PMID:12815463]

How to cite this family page

Database page citation:

SLC63 Sphingosine phosphate transporters. Accessed on 19/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1015.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.

SLC63 Sphingosine phosphate transporters C

Overview

Transporters

Further reading

References

How to cite this family page