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Paraoxonase (PON) family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Paraoxonases (PON) are calcium-dependent esterases, which may be involved in lipoprotein turnover and the conversion of lactone statin prodrugs, as well as being targets of organophosphates, such as the insecticide paraoxon.


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PON1 (paraoxonase 1) C Show summary »

PON2 (paraoxonase 2) C Show summary »

Target Id 3053
Nomenclature paraoxonase 2
Common abbreviation PON2
Previous and unofficial names arylesterase 2 | paraoxonase nirs | aromatic esterase 2 | A-esterase 2
Genes PON2 (Hs), Pon2 (Mm), Pon2 (Rn)
Ensembl ID ENSG00000105854 (Hs), ENSMUSG00000032667 (Mm), ENSRNOG00000009112 (Rn)
UniProtKB AC Q15165 (Hs), Q62086 (Mm), Q6AXM8 (Rn)
EC number
A phenyl acetate + H(2)O <=> a phenol + acetate
A N-acyl-L-homoserine lactone + H(2)O <=> a N-acyl-L-homoserine
Comment PON2 forms heterotrimers [1].

PON3 (paraoxonase 3) C Show summary »

Further reading

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How to cite this family page

Database page citation:

Paraoxonase (PON) family. Accessed on 11/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.