Basic leucine zipper domain TFs

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Basic leucine zipper domain TFs

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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This is a family of structurally divergent basic leucine zipper (bZIP) transcription factors (curated by HGNC in the Basic leucine zipper proteins gene group). The family includes the FOS, JUN, CREB, ATF, MAF and NF subgroups of transcription factors.

Targets

NRF2 (nuclear factor, erythroid 2 like 2) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3057
Nomenclature	nuclear factor, erythroid 2 like 2
Common abbreviation	NRF2
Previous and unofficial names	nuclear factor, erythroid derived 2, like 2 \| nuclear factor \| NF-E2-related factor 2 \| nuclear factor, erythroid 2-like 2
Genes	NFE2L2 (Hs), Nfe2l2 (Mm), Nfe2l2 (Rn)
Ensembl ID	ENSG00000116044 (Hs), ENSMUSG00000015839 (Mm), ENSRNOG00000001548 (Rn)
UniProtKB AC	Q16236 (Hs), Q60795 (Mm), O54968 (Rn)
Comment	NRF2 is a transcription factor that activates expression of genes containing the antioxidant response element (ARE) and is involved in the cellular response to oxidative stress.

How to cite this family page

Database page citation:

Basic leucine zipper domain TFs. Accessed on 02/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1019.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Cidlowski JA, Davenport AP, Fabbro D, Spedding M, Striessnig J, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets. Br J Pharmacol. 182: S1-S23.