Rho GEFs

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Guanine nucleotide exchange factors (GEFs)
Rho GEFs

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Targets

SOS Ras/Rac guanine nucleotide exchange factor 1 Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3096
Nomenclature	SOS Ras/Rac guanine nucleotide exchange factor 1
Previous and unofficial names	GF1 \| gingival fibromatosis, hereditary, 1 (GINGF) \| HGF \| son of sevenless homolog 1 (Drosophila) \| SOS-1
Genes	SOS1 (Hs), Sos1 (Mm), Sos1 (Rn)
Ensembl ID	ENSG00000115904 (Hs), ENSMUSG00000024241 (Mm), ENSRNOG00000007106 (Rn)
UniProtKB AC	Q07889 (Hs), Q62245 (Mm)
Comment	SOS1 regulates the KRAS GDP-GTP cycle. It is required for nucleotide exchange and formation of 'active' GTP-bound KRAS.

How to cite this family page

Database page citation:

Rho GEFs. Accessed on 11/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1025.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.