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Glycine recycling

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The glycine cleavage system (a.k.a. the glycine decarboxylase complex) is active at mitochondria. It contains four loosely associated proteins that catalyse the following (reversible) reaction: Glycine + tetrahydrofolate + NAD+ <-> 5,10-methylenetetrahydrofolate + CO2 + NH3 + NADH + H+.


glycine cleavage system protein H Show summary » More detailed page


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How to cite this family page

Database page citation:

Glycine recycling. Accessed on 27/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.