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Cytolytic pore-forming proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Complement component C9 and perforin 1 are proteins of the humoral and cell-mediated immune reponses respectively. They are both synthesised as soluble monomers but oligomerise to form cell membrane-penetrating pores which trigger target cell death. C9 pores mediate complement-initiated cytotoxicity (as the terminal event of membrane attack complex activation) and perforin 1 pores are responsible for cell-mediated cytotoxicity [1-2].

Targets

perforin 1 Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Cytolytic pore-forming proteins. Accessed on 16/12/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1028.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.