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Acyl-CoA synthetases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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ACSS2 is a monomeric cytosolic enzyme that catalyses the formation of acetyl-CoA from acetate, CoA, and ATP. It plays a role in the biosynthesis of cholesterol, glucose, and fatty acids. ACSS2 is also a drug target for cancer and neurodegenerative diseases [1].


acyl-CoA synthetase short chain family member 2 Show summary » More detailed page


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How to cite this family page

Database page citation:

Acyl-CoA synthetases. Accessed on 20/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.