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Metal-dependent protein phosphatase (PPM) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The PPM proteins (also known as the PPC2 phosphatases) are metal-dependent Ser/Thr protein phosphatases. Twenty PPM isoforms have been identified in mammals ( PPM1A, PPM1B, PPM1D, PPM1E, PPM1F, PPM1G, PPM1H, PPM1J, PPM1K, PPM1L, PPM1M, PPM1N, ILKAP, PDP1, PDP2, PHLPP1, PHLPP2, PP2D1, PPTC7, and TAB1) [2]. They are known to be involved in the negative regulation of cell stress responses.

Enzymes

protein phosphatase, Mg2+/Mn2+ dependent 1D Show summary »

Further reading

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References

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How to cite this family page

Database page citation:

Metal-dependent protein phosphatase (PPM) family. Accessed on 31/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1041.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.