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Metal-dependent protein phosphatase (PPM) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The PPM proteins (also known as the PPC2 phosphatases) are metal-dependent Ser/Thr protein phosphatases. Twenty PPM isoforms have been identified in mammals ( PPM1A, PPM1B, PPM1D, PPM1E, PPM1F, PPM1G, PPM1H, PPM1J, PPM1K, PPM1L, PPM1M, PPM1N, ILKAP, PDP1, PDP2, PHLPP1, PHLPP2, PP2D1, PPTC7, and TAB1) [2]. They are known to be involved in the negative regulation of cell stress responses.


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protein phosphatase, Mg2+/Mn2+ dependent 1D Show summary »

Target Id 3134
Nomenclature protein phosphatase, Mg2+/Mn2+ dependent 1D
Previous and unofficial names PP2C-DELTA | protein phosphatase 1D magnesium-dependent, delta isoform | protein phosphatase 2C, delta isoform | wild-type p53-induced phosphatase 1 | Wip1
Genes PPM1D (Hs)
Ensembl ID ENSG00000170836 (Hs)
UniProtKB AC O15297 (Hs)
SL-176 pIC50 7.0 [3]
Selective allosteric modulators
GSK2830371 (Inhibition) pIC50 7.9 [1], 7.1 [3]
Comment PPM1D is a p53 inducible serine/threonine phosphatase that is essential for the relief of p53-dependent checkpoint mediated cell cycle arrest. Overexpression, mutation, and gene amplification of PPM1D is reported in many tumour types, making this protein a target for cancer therapy.

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How to cite this family page

Database page citation:

Metal-dependent protein phosphatase (PPM) family. Accessed on 27/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.