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Metal-dependent protein phosphatase (PPM) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The PPM proteins (also known as the PPC2 phosphatases) are metal-dependent Ser/Thr protein phosphatases. Twenty PPM isoforms have been identified in mammals ( PPM1A, PPM1B, PPM1D, PPM1E, PPM1F, PPM1G, PPM1H, PPM1J, PPM1K, PPM1L, PPM1M, PPM1N, ILKAP, PDP1, PDP2, PHLPP1, PHLPP2, PP2D1, PPTC7, and TAB1) [2]. They are known to be involved in the negative regulation of cell stress responses.

Enzymes

3134
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protein phosphatase, Mg2+/Mn2+ dependent 1D Show summary »


Target Id 3134
Nomenclature protein phosphatase, Mg2+/Mn2+ dependent 1D
Previous and unofficial names PP2C-DELTA | protein phosphatase 1D magnesium-dependent, delta isoform | protein phosphatase 2C, delta isoform | wild-type p53-induced phosphatase 1 | Wip1
Genes PPM1D (Hs)
Ensembl ID ENSG00000170836 (Hs)
UniProtKB AC O15297 (Hs)
Inhibitors
SL-176 pIC50 7.0 [3]
Selective allosteric modulators
GSK2830371 (Inhibition) pIC50 7.9 [1], 7.1 [3]
Comment PPM1D is a p53 inducible serine/threonine phosphatase that is essential for the relief of p53-dependent checkpoint mediated cell cycle arrest. Overexpression, mutation, and gene amplification of PPM1D is reported in many tumour types, making this protein a target for cancer therapy.

Further reading

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References

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How to cite this family page

Database page citation:

Metal-dependent protein phosphatase (PPM) family. Accessed on 27/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1041.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.