Membrane bound O-acyltransferases

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Membrane bound O-acyltransferases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The membrane bound O-acyltransferase (MBOAT) proteins form an evolutionarily conserved family of acyltransferase enzymes [1-2]. In humans there are eight MBOAT genes. MBOATs catalyse the transfer of an acyl group from an acyl-coenzyme or accessory protein to their target substrates. Family members are involved in many biological processes, including neutral lipid biosynthesis, protein/peptide acylation and phospholipid re-modelling.

Enzymes

porcupine O-acyltransferase Show summary »« Hide summary More detailed page go icon to follow link

Target Id

3145

Nomenclature

porcupine O-acyltransferase

Previous and unofficial names

protein-serine O-palmitoleoyltransferase porcupine | PORC

Genes

PORCN (Hs), Porcn (Mm), Porcn (Rn)

Ensembl ID

ENSG00000102312 (Hs), ENSMUSG00000031169 (Mm), ENSRNOG00000004819 (Rn)

UniProtKB AC

Q9H237 (Hs), Q9JJJ7 (Mm)

EC number

2.3.1.250

(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA

Comment

Wnt ligands must be post-translationally modified by serine palmitoleylation, in order to facilitate secretion and binding to frizzled receptors. Procupine catalyses this serine modification. It is an oncology and fibrosis drug target.

References

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How to cite this family page

Database page citation:

Membrane bound O-acyltransferases. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1042.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.