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SLC66 Lysosomal amino acid transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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This is a family of 5 evolutionarily related proteins. Their structural similarities suggest that they are transporters. Biochemical evidence supports transporter activity for SLC66A1 (LAAT1) and SLC66A4 (CTNS; Cystinosin), primarily exporting amino acids from the lysosome to the cytoplasm. The functions of the 3 remaining members of the family are undetermined.


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solute carrier family 66 member 1 / SLC66A1 C Show summary »

solute carrier family 66 member 2 / SLC66A2 C Show summary »

solute carrier family 66 member 3 / SLC66A3 C Show summary »

cystinosin, lysosomal cystine transporter / SLC66A4 C Show summary »

mannose-P-dolichol utilization defect 1 / SLC66A5 C Show summary »

Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.