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SLC66 Lysosomal amino acid transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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This is a family of 5 evolutionarily related proteins. Their structural similarities suggest that they are transporters. Biochemical evidence supports transporter activity for SLC66A1 (LAAT1) and SLC66A4 (CTNS; Cystinosin). The functions of the 3 remaining members of the family are undetermined.


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solute carrier family 66 member 1 / SLC66A1 C Show summary »

Target Id 3160
Nomenclature solute carrier family 66 member 1
Systematic nomenclature SLC66A1
Previous and unofficial names LAAT-1 | LAAT1 | lysosomal amino acid transporter 1 homolog | PQLC2 | PQ loop repeat containing 2
Genes SLC66A1 (Hs), Slc66a1 (Mm), Slc66a1 (Rn)
Ensembl ID ENSG00000040487 (Hs), ENSMUSG00000028744 (Mm), ENSRNOG00000017706 (Rn)
UniProtKB AC Q6ZP29 (Hs), Q8C4N4 (Mm), B0BMY1 (Rn)
Comment Responsible for lysine and arginine export from lysosomes [2].

solute carrier family 66 member 2 / SLC66A2 C Show summary »

solute carrier family 66 member 3 / SLC66A3 C Show summary »

cystinosin, lysosomal cystine transporter / SLC66A4 C Show summary »

mannose-P-dolichol utilization defect 1 / SLC66A5 C Show summary »

Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.