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SLC66 Lysosomal amino acid transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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This is a family of 5 evolutionarily related proteins. Their structural similarities suggest that they are transporters. Biochemical evidence supports transporter activity for SLC66A1 (LAAT1) and SLC66A4 (CTNS; Cystinosin). The functions of the 3 remaining members of the family are undetermined.


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solute carrier family 66 member 1 / SLC66A1 C Show summary »

solute carrier family 66 member 2 / SLC66A2 C Show summary »

solute carrier family 66 member 3 / SLC66A3 C Show summary »

cystinosin, lysosomal cystine transporter / SLC66A4 C Show summary »

mannose-P-dolichol utilization defect 1 / SLC66A5 C Show summary »

Target Id 3164
Nomenclature mannose-P-dolichol utilization defect 1
Systematic nomenclature SLC66A5
Previous and unofficial names Lec35 | PQLC5 | SL15
Genes MPDU1 (Hs), Mpdu1 (Mm), Mpdu1 (Rn)
Ensembl ID ENSG00000129255 (Hs), ENSMUSG00000018761 (Mm), ENSRNOG00000012162 (Rn)
UniProtKB AC O75352 (Hs)

Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.