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CYP2 family: physiological enzymes subset C

Overview

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Compared to the other CYP2 family enzymes, this subset have physiological rather than drug metabolising enzyme activities.

Enzymes

1333
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CYP2R1 C Show summary »


Target Id 1333
Nomenclature CYP2R1
Previous and unofficial names Vitamin D 25-hydroxylase | cytochrome P450, family 2, subfamily R, polypeptide 1 | cytochrome P450, family 2, subfamily r, polypeptide 1 | cytochrome P450
Genes CYP2R1 (Hs), Cyp2r1 (Mm), Cyp2r1 (Rn)
Ensembl ID ENSG00000186104 (Hs), ENSMUSG00000030670 (Mm), ENSRNOG00000011367 (Rn)
UniProtKB AC Q6VVX0 (Hs), Q6VVW9 (Mm)
EC number
1.14.13.15
Comment Converts vitamin D3 to calcifediol [1]. Expressed in CD34+ human cord blood hematopoietic stem and early progenitor cells [8].

CYP2S1 C Show summary »

CYP2U1 C Show summary »

CYP2W1 C Show summary »

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.