Acylated lysine reader proteins

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Acylated lysine reader proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Targets

ENL (MLLT1 super elongation complex subunit) Show summary »« Hide summary

Target Id

3183

Nomenclature

MLLT1 super elongation complex subunit

Common abbreviation

ENL

Previous and unofficial names

Genes

MLLT1 (Hs), Mllt1 (Mm), Mllt1 (Rn)

Ensembl ID

ENSG00000130382 (Hs), ENSMUSG00000024212 (Mm), ENSRNOG00000048736 (Rn)

UniProtKB AC

Q03111 (Hs)

Inhibitors

SR-0813 pK_d 7.5 [1]

Comment

ENL is a chromatin reader that contains a YEATS domain that recognises acylated lysine side chains within the amino-terminal tails of histone H3. It acts as a co-activator within the transcriptional super elongation complex (SEC). ENL has been identified as a driving factor in an aggressive subset of acute leukemia with oncogenic rearrangements of the multiple lineage leukemia (MLL) gene. This suggests that inhibiting ENL's interaction with acylated lysine marks could be leveraged as a therapeutic intervention in these cancers.

References

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How to cite this family page

Database page citation:

Acylated lysine reader proteins. Accessed on 02/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1067.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.