Top ▲

Complement system regulators

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Targets

3195
Click here for help

clusterin Show summary »


Target Id 3195
Nomenclature clusterin
Previous and unofficial names APOJ | apolipoprotein J | complement lysis inhibitor, SP-40,40 | sulfated glycoprotein 2; SGP-2
Genes CLU (Hs), Clu (Mm), Clu (Rn)
Ensembl ID ENSG00000120885 (Hs), ENSMUSG00000022037 (Mm), ENSRNOG00000016460 (Rn)
UniProtKB AC P10909 (Hs), Q06890 (Mm), P05371 (Rn)
Antibodies
sotevtamab (Binding) pKd 8.4 [1]
Comment Clusterin inhibits complement-mediated cytolysis, by preventing binding of C5b-C7 complexes to the membrane of the target cells. Anti-clusterin antibodies are in development as immunomodulators with antineoplastic potential.

References

Click here for help

Show »

How to cite this family page

Database page citation:

Complement system regulators. Accessed on 01/10/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1069.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.