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C65: Otubains

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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There are two human genes that encode otubain proteins: OTUB1 and OTUB2 [1]. They are deubiquitinases that are classified within the C65 family of cysteine proteases in the MEROPS system.


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OTU deubiquitinase, ubiquitin aldehyde binding 1 / otubain-1 Show summary »

Target Id 3208
Nomenclature OTU deubiquitinase, ubiquitin aldehyde binding 1
Systematic nomenclature otubain-1
Previous and unofficial names OTU deubiquitinase | OTB1 | OTU1 | otubain-1
Genes OTUB1 (Hs), Otub1 (Mm), Otub1 (Rn)
Ensembl ID ENSG00000167770 (Hs), ENSMUSG00000024767 (Mm), ENSRNOG00000021175 (Rn)
UniProtKB AC Q96FW1 (Hs), Q7TQI3 (Mm), B2RYG6 (Rn)
EC number
compound 61 [PMID: 36221183] pIC50 9.8 [3]
Comment A cysteine protease with deubiquitinase activity that cleaves ubiquitin from branched poly-ubiquitin chains, but not from ubiquitinated proteins. Predicted to promote immune evasion (likely via inhibiting cytokine gene transcription and immune cell functions in the tumour microenvironment) and tumourigenesis, and is therefore a molecular target for anti-tumour drug discovery [2-3].


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How to cite this family page

Database page citation:

C65: Otubains. Accessed on 29/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.