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DNA polymerases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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DNA polymerases (or DNA-directed DNA polymerases) are enzymes that catalyse the addition of deoxyribonucleotides to replicating DNA strands and they play crucial roles in the processes that repair different types of DNA damage.

Enzymes

3231
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DNA polymerase beta Show summary »


Target Id 3231
Nomenclature DNA polymerase beta
Genes POLB (Hs), Polb (Mm), Polb (Rn)
Ensembl ID ENSG00000070501 (Hs), ENSMUSG00000031536 (Mm), ENSRNOG00000019150 (Rn)
UniProtKB AC P06746 (Hs), Q8K409 (Mm), P06766 (Rn)
EC number
2.7.7.7
Inhibitors
oleanolic acid pIC50 5.6 [2]
Comment DNA polymerase beta plays a key role in the DNA base-excision repair (BER) process. Its inhibition is being explored for potential to exploit synthetic lethality (SL) as a targeted anticancer strategy, in malignancies with defects in their DNA repair pathways [5].

DNA polymerase theta Show summary »

References

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How to cite this family page

Database page citation:

DNA polymerases. Accessed on 23/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1079.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.