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β-catenin destruction complex proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The β-catenin destruction multiprotein complex negatively regulates the canonical Wnt signalling pathway by targeting β-catenin for ubiquitination and proteasomal degradation. The complex includes axin, adenomatosis polyposis coli (APC), protein phosphatase 2A (PP2A) and glycogen synthase kinase 3 (GSK3).

Targets

3237
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axin 2 Show summary »


Target Id 3237
Nomenclature axin 2
Previous and unofficial names axil | conductin
Genes AXIN2 (Hs), Axin2 (Mm), Axin2 (Rn)
Ensembl ID ENSG00000168646 (Hs), ENSMUSG00000000142 (Mm), ENSRNOG00000055010 (Rn)
UniProtKB AC Q9Y2T1 (Hs), O88566 (Mm), AXIN2_RAT (Rn)
Inhibitors
CW85319 (Binding) pKd 5.2 [2]
Comment Axin 2 is a component of the β-catenin destruction complex. Mutations in the AXIN2 gene have been linked to the development of oligodontia and colorectal cancer [1,3,5], and in colorectal cancers with defects in DNA mismatch repair genes [4].

References

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How to cite this family page

Database page citation:

β-catenin destruction complex proteins. Accessed on 18/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1081.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.