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Lipid transfer/lipopolysaccharide binding proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The lipid transfer/lipopolysaccharide binding protein (LT/LBP) family are structurally related proteins that are able to bind phospholipids and lipopolysaccharides. Family members share significant amino acid similarity and exon/intron organisation. Cholesterol ester transfer protein (CETP) and phospholipid transfer protein (PLTP) are plasma proteins that are necessary for the catabolism of high-density lipoproteins (HDL), and they have been associated with the pathogenesis of atherosclerosis. CETP has been extensively investigated as a drug target for the development of agents to treat/prevent atherosclerotic cardiovascular disease and other diseases associated with lipoprotein metabolism. Other members of this protein family include lipopolysaccharide binding protein (LBP; a plasma protein) and bactericidal/permeability-increasing protein (BPI; detected in neutrophil and eosinophil granules) which both bind to bacterial endotoxins and modulate the host response to infections by Gram-negative bacteria.

Targets

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cholesteryl ester transfer protein Show summary »

References

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How to cite this family page

Database page citation:

Lipid transfer/lipopolysaccharide binding proteins. Accessed on 16/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1088.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.