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Diacylglycerol kinases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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There are ten diacylglycerol kinase genes in humans. The enzymes (DGKs α, β, δ, ε, γ, η, ι, κ, θ and ζ) catalyse the conversion of diacylglycerol (DAG) to phosphatidic acid (PA) using ATP as the phosphate source. DGK activity is increased by receptor-mediated activation of the phosphoinositide pathway. The enzymes control switching between DAG and PA lipid signalling in cells.


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diacylglycerol kinase alpha Show summary »

diacylglycerol kinase zeta Show summary »

Target Id 3257
Nomenclature diacylglycerol kinase zeta
Previous and unofficial names DAG kinase zeta | DGK-zeta | DGKζ | diglyceride kinase zeta
Genes DGKZ (Hs), Dgkz (Mm), Dgkz (Rn)
Ensembl ID ENSG00000149091 (Hs), ENSMUSG00000040479 (Mm), ENSRNOG00000017737 (Rn)
UniProtKB AC Q13574 (Hs), A2AHJ6 (Mm), DGKZ_RAT (Rn)
EC number
BMS-502 pIC50 8.7 [1]
Comment T lymphocytes express high levels of DGKZ isoforms, where DGKZ appears to acts as a negative regulator of DAG signaling on T-cell activation [2].


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How to cite this family page

Database page citation:

Diacylglycerol kinases. Accessed on 14/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.