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Protein phosphatase catalytic subunits

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

3263
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protein phosphatase 1 catalytic subunit alpha Show summary »

protein phosphatase 2 catalytic subunit alpha Show summary »


Target Id 3263
Nomenclature protein phosphatase 2 catalytic subunit alpha
Previous and unofficial names PP2A | PP2Ac | PP2Calpha | protein phosphatase 2A catalytic subunit, alpha isoform
Genes PPP2CA (Hs), Ppp2ca (Mm), Ppp2ca (Rn)
Ensembl ID ENSG00000113575 (Hs), ENSMUSG00000020349 (Mm), ENSRNOG00000005389 (Rn)
UniProtKB AC P67775 (Hs), O88591 (Mm), P63331 (Rn)
EC number
3.1.3.16
Inhibitors
microcystin-LR pIC50 9.0 – 10.0 [1]
okadaic acid pIC50 9.0 [7]
calyculin A pIC50 8.7 [7]
cantharidin pIC50 6.7 [2]
Comment Mediates dephosphorylation of a range of substrate proteins [3-6]. PP2A is particularly important for regulating microtubule-associated protein (MAP) phosphorylation and stability [11].

References

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How to cite this family page

Database page citation:

Protein phosphatase catalytic subunits. Accessed on 13/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1092.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.