SLC28 and SLC29 families of nucleoside transporters | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY

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SLC28 and SLC29 families of nucleoside transporters

SLC28 and SLC29 families of nucleoside transporters C

Contents

Overview
Subfamilies
Further reading
References
NC-IUPHAR subcommittee and family contributors
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Overview

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Nucleoside transporters are divided into two families, the sodium-dependent, concentrative solute carrier family 28 (SLC28) and the equilibrative, solute carrier family 29 (SLC29). The endogenous substrates are typically nucleosides, although some family members can also transport nucleobases and organic cations [1].

Subfamilies

SLC28 family C
SLC29 family C

Further reading

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* Key recommended reading is highlighted with an asterisk

* Boswell-Casteel RC, Hays FA. (2017) Equilibrative nucleoside transporters-A review. Nucleosides Nucleotides Nucleic Acids, 36 (1): 7-30. [PMID:27759477]

Cano-Soldado P, Pastor-Anglada M. (2012) Transporters that translocate nucleosides and structural similar drugs: structural requirements for substrate recognition. Med Res Rev, 32 (2): 428-57. [PMID:21287570]

Dos Santos-Rodrigues A, Grañé-Boladeras N, Bicket A, Coe IR. (2014) Nucleoside transporters in the purinome. Neurochem Int, 73: 229-37. [PMID:24704797]

King AE, Ackley MA, Cass CE, Young JD, Baldwin SA. (2006) Nucleoside transporters: from scavengers to novel therapeutic targets. Trends Pharmacol Sci, 27 (8): 416-25. [PMID:16820221]

Pastor-Anglada M, Cano-Soldado P, Errasti-Murugarren E, Casado FJ. (2008) SLC28 genes and concentrative nucleoside transporter (CNT) proteins. Xenobiotica, 38 (7-8): 972-94. [PMID:18668436]

* Pastor-Anglada M, Pérez-Torras S. (2015) Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets. Front Pharmacol, 6: 13. [PMID:25713533]

* Young JD. (2016) The SLC28 (CNT) and SLC29 (ENT) nucleoside transporter families: a 30-year collaborative odyssey. Biochem Soc Trans, 44 (3): 869-76. [PMID:27284054]

* Young JD, Yao SY, Baldwin JM, Cass CE, Baldwin SA. (2013) The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol Aspects Med, 34 (2-3): 529-47. [PMID:23506887]

References

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NC-IUPHAR subcommittee and family contributors

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.