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ABCD subfamily of peroxisomal ABC transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Peroxisomes are indispensable organelles in higher eukaryotes. They are essential for the oxidation of a wide variety of metabolites, which include: saturated, monounsaturated and polyunsaturated fatty acids, branched-chain fatty acids, bile acids and dicarboxylic acids [4]. However, the peroxisomal membrane forms an impermeable barrier to these metabolites. The mammalian peroxisomal membrane harbours three ATP-binding cassette (ABC) half-transporters, named ABCD1, -2 and -3. The ABCD transporters predominantly act as homodimers to transport different acyl-CoAs.


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ALDP (ABCD1) C Show summary »

Target Id 788
Systematic nomenclature ABCD1
Common abbreviation ALDP
Previous and unofficial names Adrenoleukodystrophy protein | ALD | ALDP | AMN | ATP-binding cassette, sub-family D (ALD), member 1 | Aldgh | ATP-binding cassette, subfamily D (ALD), member 1 | ATP-binding cassette
Genes ABCD1 (Hs), Abcd1 (Mm), Abcd1 (Rn)
Ensembl ID ENSG00000101986 (Hs), ENSMUSG00000031378 (Mm), ENSRNOG00000056524 (Rn)
UniProtKB AC P33897 (Hs), P48410 (Mm)
Comment Transports coenzyme A esters (CoA) of very long chain fatty acids (VLCFA) [6-7]. Pathogenic variants in ABCD1 ( result in adrenoleukodystrophy (OMIM: 300100) [3,5].

ALDR (ABCD2) C Show summary »

PMP70 (ABCD3) C Show summary »


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.