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ABCD subfamily of peroxisomal ABC transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Peroxisomes are indispensable organelles in higher eukaryotes. They are essential for the oxidation of a wide variety of metabolites, which include: saturated, monounsaturated and polyunsaturated fatty acids, branched-chain fatty acids, bile acids and dicarboxylic acids [1,5]. However, the peroxisomal membrane forms an impermeable barrier to these metabolites. The mammalian peroxisomal membrane harbours three ATP-binding cassette (ABC) half-transporters, which act as homo- and/or heterodimers to transport these metabolites across the peroxisomal membrane.


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ALDP (ABCD1) C Show summary »

Target Id 788
Systematic nomenclature ABCD1
Common abbreviation ALDP
Previous and unofficial names Adrenoleukodystrophy protein | ALD | ALDP | AMN | ATP-binding cassette, sub-family D (ALD), member 1 | Aldgh | ATP-binding cassette, subfamily D (ALD), member 1 | ATP-binding cassette
Genes ABCD1 (Hs), Abcd1 (Mm), Abcd1 (Rn)
Ensembl ID ENSG00000101986 (Hs), ENSMUSG00000031378 (Mm), ENSRNOG00000056524 (Rn)
UniProtKB AC P33897 (Hs), P48410 (Mm)
Comment Transports coenzyme A esters of very long chain fatty acids [6-7]. Loss-of-function mutations in ABCD1 (mutation registry held by the Adrenoleukodystrophy database; result in adrenoleukodystrophy (OMIM: 300100) [4].

ALDR (ABCD2) C Show summary »

PMP70 (ABCD3) C Show summary »


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.