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ABCD subfamily of peroxisomal ABC transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Peroxisomes are indispensable organelles in higher eukaryotes. They are essential for the oxidation of a wide variety of metabolites, which include: saturated, monounsaturated and polyunsaturated fatty acids, branched-chain fatty acids, bile acids and dicarboxylic acids [1,5]. However, the peroxisomal membrane forms an impermeable barrier to these metabolites. The mammalian peroxisomal membrane harbours three ATP-binding cassette (ABC) half-transporters, which act as homo- and/or heterodimers to transport these metabolites across the peroxisomal membrane.

Transporters

789
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ALDP (ABCD1) C Show summary »

ALDR (ABCD2) C Show summary »


Target Id 789
Systematic nomenclature ABCD2
Common abbreviation ALDR
Previous and unofficial names ALDL1 | ALDR | ALDRP | adrenoleukodystrophy-related protein | ATP-binding cassette, sub-family D (ALD), member 2 | ABC39 | ATP-binding cassette, subfamily D (ALD), member 2 | ATP-binding cassette
Genes ABCD2 (Hs), Abcd2 (Mm), Abcd2 (Rn)
Ensembl ID ENSG00000173208 (Hs), ENSMUSG00000055782 (Mm), ENSRNOG00000015538 (Rn)
UniProtKB AC Q9UBJ2 (Hs), Q61285 (Mm), Q9QY44 (Rn)
Comment In vitro experiments indicate that ABCD2 has overlapping substrate specificity with ABCD1 towards saturated and monounsaturated very long-chain fatty acids, albeit at much lower specificity. ABCD2 has affinity for the polyunsaturated fatty acids C22:6-CoA and C24:6-CoA. However, in vivo proof for its true function is still lacking. No disease has yet been linked to a deficiency of ABCD2.

PMP70 (ABCD3) C Show summary »

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.