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ABCG subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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This family of 'half-transporters' act as homo- or heterodimers; particularly ABCG5 and ABCG8 are thought to be obligate heterodimers. The ABCG5/ABCG heterodimer sterol transporter structure has been determined [3], suggesting an extensive intracellular nucleotide binding domain linked to the transmembrane domains by a fold in the primary sequence. The functional ABCG2 transporter appears to be a homodimer with structural similarities to the ABCG5/ABCG8 heterodimer [1,5].

Transporters

793
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ABC8 (ABCG1) C Show summary »

ABCP (ABCG2) C Show summary » More detailed page go icon to follow link

ABCG4 C Show summary »


Target Id 793
Systematic nomenclature ABCG4
Previous and unofficial names White2 | ATP-binding cassette, subfamily G, member 4 | ATP-binding cassette, sub-family G (WHITE), member 4 | ATP-binding cassette, subfamily G (WHITE), member 4
Genes ABCG4 (Hs), Abcg4 (Mm), Abcg4 (Rn)
Ensembl ID ENSG00000172350 (Hs), ENSMUSG00000032131 (Mm), ENSRNOG00000008862 (Rn)
UniProtKB AC Q9H172 (Hs)
Comment Putative functional dependence on ABCG1

ABCG5 C Show summary »

ABCG8 C Show summary »

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.