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ABCG subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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This family of 'half-transporters' act as homo- or heterodimers; particularly ABCG5 and ABCG8 are thought to be obligate heterodimers. The ABCG5/ABCG heterodimer sterol transporter structure has been determined [3], suggesting an extensive intracellular nucleotide binding domain linked to the transmembrane domains by a fold in the primary sequence. The functional ABCG2 transporter appears to be a homodimer with structural similarities to the ABCG5/ABCG8 heterodimer [1,5].


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ABC8 (ABCG1) C Show summary »

ABCP (ABCG2) C Show summary » More detailed page go icon to follow link

ABCG4 C Show summary »

ABCG5 C Show summary »

Target Id 794
Systematic nomenclature ABCG5
Previous and unofficial names White3 | ATP-binding cassette sub-family G (WHITE) member 5 (sterolin 1) | ATP-binding cassette sub-family G member 5 | cmp | trac | STSL | ATP-binding cassette, subfamily G (WHITE), member 5
Genes ABCG5 (Hs), Abcg5 (Mm), Abcg5 (Rn)
Ensembl ID ENSG00000138075 (Hs), ENSMUSG00000040505 (Mm), ENSRNOG00000005250 (Rn)
UniProtKB AC Q9H222 (Hs), Q99PE8 (Mm), Q99PE7 (Rn)
Comment The ABCG5/ABCG8 heterodimer transports phytosterols and cholesterol [3]. Loss-of-function mutations in ABCG5 or ABCG8 are associated with sitosterolemia (OMIM: 210250).

ABCG8 C Show summary »


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.