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F-type ATPase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The F-type ATPase, also known as ATP synthase or ATP phosphohydrolase (H+-transporting), is a mitochondrial membrane-associated multimeric complex consisting of two domains, an F0 channel domain in the membrane and an F1 domain extending into the lumen. Proton transport across the inner mitochondrial membrane is used to drive the synthesis of ATP, although it is also possible for the enzyme to function as an ATPase. The ATP5O subunit (oligomycin sensitivity-conferring protein, OSCP, (P48047)), acts as a connector between F1 and F0 motors.

The F1 motor, responsible for ATP turnover, has the subunit composition α3β3γδε.

The F0 motor, responsible for ion translocation, is complex in mammals, with probably nine subunits centring on A, B, and C subunits in the membrane, together with D, E, F2, F6, G2 and 8 subunits. Multiple pseudogenes for the F0 motor proteins have been defined in the human genome.

Transporters

796
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F-type ATPase α subunit Show summary »


Target Id 796
Nomenclature F-type ATPase α subunit
Previous and unofficial names ATP5A | ATP5AL2 | ATPM | OMR | ORM | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle | ATP synthase subunit alpha, mitochondrial | mitochondrial H+-ATP synthase alpha subunit | Mom2 | ATP synthase, H transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle | ATP synthase | ATP5A1 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 | Atp5a1
Genes ATP5F1A (Hs), Atp5a1 (Mm), Atp5f1a (Rn)
Ensembl ID ENSG00000152234 (Hs), ENSMUSG00000025428 (Mm), ENSRNOG00000017032 (Rn)
UniProtKB AC P25705 (Hs), Q03265 (Mm), P15999 (Rn)

F-type ATPase β subunit Show summary »

F-type ATPase γ subunit Show summary »

F-type ATPase δ subunit Show summary »

F-type ATPase ε subunit Show summary »

F-type ATPase A subunit Show summary »

F-type ATPase B subunit Show summary »

F-type ATPase C subunit Show summary »

F-type ATPase D subunit Show summary »

F-type ATPase E subunit Show summary »

F-type ATPase F2 subunit Show summary »

F-type ATPase F6 subunit Show summary »

F-type ATPase G2 subunit Show summary »

F-type ATPase 8 subunit Show summary »

How to cite this family page

Database page citation:

F-type ATPase. Accessed on 29/11/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=156.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.