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F-type ATPase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The F-type ATPase, also known as ATP synthase or ATP phosphohydrolase (H+-transporting), is a mitochondrial membrane-associated multimeric complex consisting of two domains, an F0 channel domain in the membrane and an F1 domain extending into the lumen. Proton transport across the inner mitochondrial membrane is used to drive the synthesis of ATP, although it is also possible for the enzyme to function as an ATPase. The ATP5O subunit (oligomycin sensitivity-conferring protein, OSCP, (P48047)), acts as a connector between F1 and F0 motors.

The F1 motor, responsible for ATP turnover, has the subunit composition α3β3γδε.

The F0 motor, responsible for ion translocation, is complex in mammals, with probably nine subunits centring on A, B, and C subunits in the membrane, together with D, E, F2, F6, G2 and 8 subunits. Multiple pseudogenes for the F0 motor proteins have been defined in the human genome.

Transporters

805
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F-type ATPase α subunit Show summary »

F-type ATPase β subunit Show summary »

F-type ATPase γ subunit Show summary »

F-type ATPase δ subunit Show summary »

F-type ATPase ε subunit Show summary »

F-type ATPase A subunit Show summary »

F-type ATPase B subunit Show summary »

F-type ATPase C subunit Show summary »

F-type ATPase D subunit Show summary »

F-type ATPase E subunit Show summary »


Target Id 805
Nomenclature F-type ATPase E subunit
Previous and unofficial names ATP5K | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit e | ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit e | ATPase subunit e | Lfm1 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E | ATP synthase, H transporting, mitochondrial Fo complex, subunit E | ATP synthase | ATP5I | ATP synthase, H+ transporting, mitochondrial Fo complex subunit E | ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit E | Atp5i
Genes ATP5ME (Hs), Atp5k (Mm), Atp5me (Rn)
Ensembl ID ENSG00000169020 (Hs), ENSMUSG00000050856 (Mm), ENSRNOG00000000064 (Rn)
UniProtKB AC P56385 (Hs), Q06185 (Mm), P29419 (Rn)

F-type ATPase F2 subunit Show summary »

F-type ATPase F6 subunit Show summary »

F-type ATPase G2 subunit Show summary »

F-type ATPase 8 subunit Show summary »

How to cite this family page

Database page citation:

F-type ATPase. Accessed on 18/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=156.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.