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Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [2], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been reviewed in detail [1]. The GPCRs in Table 1 are all Class A, rhodopsin-like GPCRs. Class A orphan GPCRs not listed in Table 1 are putative GPCRs with as-yet unidentified endogenous ligands.
Table 1: Class A orphan GPCRs with putative endogenous ligands
| GPR3 | GPR4 | GPR6 | GPR12 | GPR15 | GPR17 | GPR20 |
| GPR22 | GPR26 | GPR31 | GPR34 | GPR35 | GPR37 | GPR39 |
| GPR50 | GPR63 | GPR65 | GPR68 | GPR75 | GPR84 | GPR87 |
| GPR88 | GPR132 | GPR149 | GPR161 | GPR183 | LGR4 | LGR5 |
| LGR6 | MAS1 | MRGPRD | MRGPRX1 | MRGPRX2 | P2RY10 | TAAR2 |
In addition the orphan receptors GPR18, GPR55 and GPR119 which are reported to respond to endogenous agents analogous to the endogenous cannabinoid ligands have been grouped together (GPR18, GPR55 and GPR119).
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Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: G protein-coupled receptors. Br J Pharmacol. 176 Issue S1: S21-S141.
