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Alanine/serine/cysteine transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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ASC transporters mediate Na+-dependent exchange of small neutral amino acids such as Ala, Ser, Cys and Thr and their structure is predicted to be similar to that of the glutamate transporters [2,10]. ASCT1 and ASCT2 also exhibit thermodynamically uncoupled chloride channel activity associated with substrate transport [1,4,11]. Whereas EAATs counter-transport K+ (see above) ASCTs do not and their function is independent of the intracellular concentration of K+ [1,11].


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ASCT1 (Alanine/serine/cysteine transporter 1 / SLC1A4) C Show summary »

ASCT2 (Alanine/serine/cysteine transporter 2 / SLC1A5) C Show summary » More detailed page go icon to follow link


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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.