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Alanine/serine/cysteine transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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ASC transporters mediate Na+-dependent exchange of small neutral amino acids such as Ala, Ser, Cys and Thr and their structure is predicted to be similar to that of the glutamate transporters [2,10]. ASCT1 and ASCT2 also exhibit thermodynamically uncoupled chloride channel activity associated with substrate transport [1,4,11]. Whereas EAATs counter-transport K+ (see above) ASCTs do not and their function is independent of the intracellular concentration of K+ [1,11].

Transporters

873
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ASCT1 (Alanine/serine/cysteine transporter 1 / SLC1A4) C Show summary »


Target Id 873
Nomenclature Alanine/serine/cysteine transporter 1
Systematic nomenclature SLC1A4
Common abbreviation ASCT1
Previous and unofficial names Neutral amino acid transporter A | ASCT1 | SATT | alanine/serine/cysteine/threonine transporter | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | solute carrier family 1 (glutamate/neutral amino acid transporter)
Genes SLC1A4 (Hs), Slc1a4 (Mm), Slc1a4 (Rn)
Ensembl ID ENSG00000115902 (Hs), ENSMUSG00000020142 (Mm), ENSRNOG00000005248 (Rn)
UniProtKB AC P43007 (Hs), O35874 (Mm)
Bioparadigms SLC Tables SLC1A4 (Hs)
RESOLUTE SLC1A4 (Hs)
Endogenous substrates L-cysteine > L-alanine = L-serine > L-threonine
Stoichiometry 1 Na+: 1 amino acid (in): 1 Na+: 1 amino acid (out); (homo-, or hetero-exchange; [12])

ASCT2 (Alanine/serine/cysteine transporter 2 / SLC1A5) C Show summary » More detailed page go icon to follow link

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.