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SLC7 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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SLC7 family members may be divided into two major groups: cationic amino acid transporters (CATs) and glycoprotein-associated amino acid transporters (gpaATs).

Cationic amino acid transporters are 14 TM proteins, which mediate pH- and sodium-independent transport of cationic amino acids (system y+), apparently as an exchange mechanism. These transporters are sensitive to inhibition by N-ethylmaleimide.


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CAT1 (High affinity cationic amino acid transporter 1 / SLC7A1) C Show summary »

CAT2 (Low affinity cationic amino acid transporter 2 / SLC7A2) C Show summary »

CAT3 (Cationic amino acid transporter 3 / SLC7A3) C Show summary »

CAT4 (Cationic amino acid transporter 4 / SLC7A4) Show summary »

Target Id 894
Nomenclature Cationic amino acid transporter 4
Systematic nomenclature SLC7A4
Common abbreviation CAT4
Previous and unofficial names VH | solute carrier family 7 (cationic amino acid transporter, y+ system), member 4 | solute carrier family 7 (orphan transporter), member 4 | solute carrier family 7, member 4 | solute carrier family 7 | solute carrier family 7 (cationic amino acid transporter
Genes SLC7A4 (Hs), Slc7a4 (Mm), Slc7a4 (Rn)
Ensembl ID ENSG00000099960 (Hs), ENSMUSG00000022756 (Mm), ENSRNOG00000001874 (Rn)
UniProtKB AC O43246 (Hs), Q8BLQ7 (Mm)
Bioparadigms SLC Tables SLC7A4 (Hs)

Probable cationic amino acid transporter / SLC7A14 Show summary »

LAT1 (L-type amino acid transporter 1 / SLC7A5) C Show summary » More detailed page go icon to follow link

LAT2 (L-type amino acid transporter 2 / SLC7A8) C Show summary »

y+LAT1 (y+L amino acid transporter 1 / SLC7A7) C Show summary »

y+LAT2 (y+L amino acid transporter 2 / SLC7A6) C Show summary »

b0,+AT (b0,+-type amino acid transporter 1 / SLC7A9) C Show summary »

Asc-1 (Asc-type amino acid transporter 1 / SLC7A10) C Show summary »

xCT (Cystine/glutamate transporter / SLC7A11) C Show summary »

AGT1 / SLC7A13 C Show summary »


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Further reading

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.