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SLC7 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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SLC7 family members may be divided into two major groups: cationic amino acid transporters (CATs) and glycoprotein-associated amino acid transporters (gpaATs).

Cationic amino acid transporters are 14 TM proteins, which mediate pH- and sodium-independent transport of cationic amino acids (system y+), apparently as an exchange mechanism. These transporters are sensitive to inhibition by N-ethylmaleimide.

Transporters

901
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CAT1 (High affinity cationic amino acid transporter 1 / SLC7A1) C Show summary »

CAT2 (Low affinity cationic amino acid transporter 2 / SLC7A2) C Show summary »

CAT3 (Cationic amino acid transporter 3 / SLC7A3) C Show summary »

CAT4 (Cationic amino acid transporter 4 / SLC7A4) Show summary »

Probable cationic amino acid transporter / SLC7A14 Show summary »

LAT1 (L-type amino acid transporter 1 / SLC7A5) C Show summary » More detailed page go icon to follow link

LAT2 (L-type amino acid transporter 2 / SLC7A8) C Show summary »

y+LAT1 (y+L amino acid transporter 1 / SLC7A7) C Show summary »

y+LAT2 (y+L amino acid transporter 2 / SLC7A6) C Show summary »

b0,+AT (b0,+-type amino acid transporter 1 / SLC7A9) C Show summary »

Asc-1 (Asc-type amino acid transporter 1 / SLC7A10) C Show summary »


Target Id 901
Nomenclature Asc-type amino acid transporter 1
Systematic nomenclature SLC7A10
Common abbreviation Asc-1
Previous and unofficial names D- and L-serine transporter Asc-1 | solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 | solute carrier family 7 member 10 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 | solute carrier family 7 (cationic amino acid transporter
Genes SLC7A10 (Hs), Slc7a10 (Mm), Slc7a10 (Rn)
Ensembl ID ENSG00000130876 (Hs), ENSMUSG00000030495 (Mm), ENSRNOG00000010938 (Rn)
UniProtKB AC Q9NS82 (Hs), P63115 (Mm), P63116 (Rn)
Bioparadigms SLC Tables SLC7A10 (Hs)
RESOLUTE SLC7A10 (Hs)

xCT (Cystine/glutamate transporter / SLC7A11) C Show summary »

AGT1 / SLC7A13 C Show summary »

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References

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.