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SLC7 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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SLC7 family members may be divided into two major groups: cationic amino acid transporters (CATs) and glycoprotein-associated amino acid transporters (gpaATs).

Cationic amino acid transporters are 14 TM proteins, which mediate pH- and sodium-independent transport of cationic amino acids (system y+), apparently as an exchange mechanism. These transporters are sensitive to inhibition by N-ethylmaleimide.

Transporters

902
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CAT1 (High affinity cationic amino acid transporter 1 / SLC7A1) C Show summary »

CAT2 (Low affinity cationic amino acid transporter 2 / SLC7A2) C Show summary »

CAT3 (Cationic amino acid transporter 3 / SLC7A3) C Show summary »

CAT4 (Cationic amino acid transporter 4 / SLC7A4) Show summary »

Probable cationic amino acid transporter / SLC7A14 Show summary »

LAT1 (L-type amino acid transporter 1 / SLC7A5) C Show summary » More detailed page go icon to follow link

LAT2 (L-type amino acid transporter 2 / SLC7A8) C Show summary »

y+LAT1 (y+L amino acid transporter 1 / SLC7A7) C Show summary »

y+LAT2 (y+L amino acid transporter 2 / SLC7A6) C Show summary »

b0,+AT (b0,+-type amino acid transporter 1 / SLC7A9) C Show summary »

Asc-1 (Asc-type amino acid transporter 1 / SLC7A10) C Show summary »

xCT (Cystine/glutamate transporter / SLC7A11) C Show summary »


Target Id 902
Nomenclature Cystine/glutamate transporter
Systematic nomenclature SLC7A11
Common abbreviation xCT
Previous and unofficial names cystine/glutamate exchanger | solute carrier family 7 (anionic amino acid transporter light chain, x-c-- system), member 11 | sut | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 | solute carrier family 7 (cationic amino acid transporter
Genes SLC7A11 (Hs), Slc7a11 (Mm), Slc7a11 (Rn)
Ensembl ID ENSG00000151012 (Hs), ENSMUSG00000027737 (Mm), ENSRNOG00000010210 (Rn)
UniProtKB AC Q9UPY5 (Hs), Q9WTR6 (Mm)
Bioparadigms SLC Tables SLC7A11 (Hs)
Inhibitors
quisqualate pIC50 5.3 [1]

AGT1 / SLC7A13 C Show summary »

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References

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.