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Choline transporter C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The high affinity, hemicholinium-3-sensitive, choline transporter (CHT) is expressed mainly in cholinergic neurones on nerve cell terminals and synaptic vesicles (keratinocytes being an additional location). In autonomic neurones, expression of CHT requires an activity-dependent retrograde signal from postsynaptic neurones [5]. Through recapture of choline generated by the hydrolysis of ACh by acetylcholinesterase, CHT serves to maintain acetylcholine synthesis within the presynaptic terminal [3]. Homozygous mice engineered to lack CHT die within one hour of birth as a result of hypoxia arising from failure of transmission at the neuromuscular junction of the skeletal muscles that support respiration [2]. A low affinity choline uptake mechanism that remains to be identified at the molecular level may involve multiple transporters. In addition, a family of choline transporter-like (CTL) proteins, (which are members of the SLC44 family) with weak Na+ dependence have been described [8].

Transporters

914
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CHT / SLC5A7 C Show summary »


Target Id 914
Nomenclature CHT
Systematic nomenclature SLC5A7
Previous and unofficial names choline transporter 1 | CHT1 | hemicholinium-3-sensitive choline transporter | high affinity choline transporter 1 | solute carrier family 5 (choline transporter) member 7 | solute carrier family 5 (sodium/choline cotransporter), member 7 | solute carrier family 5 (choline transporter)
Genes SLC5A7 (Hs), Slc5a7 (Mm), Slc5a7 (Rn)
Ensembl ID ENSG00000115665 (Hs), ENSMUSG00000023945 (Mm), ENSRNOG00000010597 (Rn)
UniProtKB AC Q9GZV3 (Hs), Q8BGY9 (Mm), Q9JMD7 (Rn)
Bioparadigms SLC Tables SLC5A7 (Hs)
RESOLUTE SLC5A7 (Hs)
Endogenous substrates
choline
Substrates
triethylcholine
Selective inhibitors
hemicholinium-3 pKi 7.0 – 8.0 [7]
Labelled ligands
[3H]hemicholinium-3 pKd 8.2 – 8.4
Stoichiometry Na+ : choline (variable stoichimetry); modulated by extracellular Cl- [4]

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How to cite this family page

Database page citation:

Choline transporter. Accessed on 01/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=172.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.