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Hexose transporter family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Detailed characterisation of members of the hexose transporter family is limited to SGLT1, 2 and 3, which are all inhibited in a competitive manner by phlorizin, a natural dihydrocholine glucoside, that exhibits modest selectivity towards SGLT2 (see [8] for an extensive review). SGLT1 is predominantly expressed in the small intestine, mediating the absorption of glucose (e.g. D-glucose), but also occurs in the brain, heart and in the late proximal straight tubule of the kidney. The expression of SGLT2 is almost exclusively restricted to the early proximal convoluted tubule of the kidney, where it is largely responsible for the renal reabsorption of glucose. SGLT3 is not a transporter but instead acts as a glucosensor generating an inwardly directed flux of Na+ that causes membrane depolarization [2].

Transporters

918
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SGLT1 (Sodium/glucose cotransporter 1 / SLC5A1) C Show summary » More detailed page go icon to follow link

SGLT2 (Sodium/glucose cotransporter 2 / SLC5A2) C Show summary » More detailed page go icon to follow link

SGLT3 (Low affinity sodium-glucose cotransporter / SLC5A4) C Show summary »

SGLT4 (Sodium/glucose cotransporter 4 / SLC5A9) C Show summary »


Target Id 918
Nomenclature Sodium/glucose cotransporter 4
Systematic nomenclature SLC5A9
Common abbreviation SGLT4
Previous and unofficial names solute carrier family 5 (sodium/glucose cotransporter), member 9 | solute carrier family 5 (sodium/sugar cotransporter), member 9 | solute carrier family 5 (sodium/glucose cotransporter)
Genes SLC5A9 (Hs), Slc5a9 (Mm), Slc5a9 (Rn)
Ensembl ID ENSG00000117834 (Hs), ENSMUSG00000028544 (Mm), ENSRNOG00000042950 (Rn)
UniProtKB AC Q2M3M2 (Hs), Q8VDT1 (Mm)
Bioparadigms SLC Tables SLC5A9 (Hs)
Substrates
D-glucose
α-MDG
D-mannose

SGLT5 (Sodium/glucose cotransporter 5 / SLC5A10) C Show summary »

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References

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How to cite this family page

Database page citation:

Hexose transporter family. Accessed on 20/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=173.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.