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GABA transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The activity of GABA-transporters located predominantly upon neurones (GAT-1), glia (GAT-3) or both (GAT-2, BGT-1) serves to terminate phasic GABA-ergic transmission, maintain low ambient extracellular concentrations of GABA, and recycle GABA for reuse by neurones. Nonetheless, ambient concentrations of GABA are sufficient to sustain tonic inhibition mediated by high affinity GABAA receptors in certain neuronal populations [18]. GAT1 is the predominant GABA transporter in the brain and occurs primarily upon the terminals of presynaptic neurones and to a much lesser extent upon distal astocytic processes that are in proximity to axons terminals. GAT3 resides predominantly on distal astrocytic terminals that are close to the GABAergic synapse. By contrast, BGT1 occupies an extrasynaptic location possibly along with GAT2 which has limited expression in the brain [15]. TauT is a high affinity taurine transporter involved in osmotic balance that occurs in the brain and non-neuronal tissues, such as the kidney, brush border membrane of the intestine and blood brain barrier [4,12]. CT1, which transports creatine, has a ubiquitous expression pattern, often co-localizing with creatine kinase [4].

Transporters

930
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GAT1 / SLC6A1 C Show summary » More detailed page go icon to follow link

GAT2 / SLC6A13 C Show summary »


Target Id 930
Nomenclature GAT2
Systematic nomenclature SLC6A13
Previous and unofficial names sodium- and chloride-dependent GABA transporter 2 | Gabt3 | GAT3 | solute carrier family 6 (neurotransmitter transporter, GABA), member 13 | solute carrier family 6 (neurotransmitter transporter), member 13 | solute carrier family 6 (neurotransmitter transporter
Genes SLC6A13 (Hs), Slc6a13 (Mm), Slc6a13 (Rn)
Ensembl ID ENSG00000010379 (Hs), ENSMUSG00000030108 (Mm), ENSRNOG00000012876 (Rn)
UniProtKB AC Q9NSD5 (Hs), P31649 (Mm), P31646 (Rn)
Bioparadigms SLC Tables SLC6A13 (Hs)
Endogenous substrates
GABA
β-alanine
Substrates
nipecotic acid
guvacine
Selective inhibitors
SNAP-5114 pIC50 4.7 [2] - Rat
Stoichiometry 2Na+: 1Cl-:1GABA

GAT3 / SLC6A11 C Show summary »

BGT1 / SLC6A12 C Show summary »

TauT / SLC6A6 C Show summary »

CT1 / SLC6A8 C Show summary »

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.