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GABA transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The activity of GABA-transporters located predominantly upon neurones (GAT-1), glia (GAT-3) or both (GAT-2, BGT-1) serves to terminate phasic GABA-ergic transmission, maintain low ambient extracellular concentrations of GABA, and recycle GABA for reuse by neurones. Nonetheless, ambient concentrations of GABA are sufficient to sustain tonic inhibition mediated by high affinity GABAA receptors in certain neuronal populations [18]. GAT1 is the predominant GABA transporter in the brain and occurs primarily upon the terminals of presynaptic neurones and to a much lesser extent upon distal astocytic processes that are in proximity to axons terminals. GAT3 resides predominantly on distal astrocytic terminals that are close to the GABAergic synapse. By contrast, BGT1 occupies an extrasynaptic location possibly along with GAT2 which has limited expression in the brain [15]. TauT is a high affinity taurine transporter involved in osmotic balance that occurs in the brain and non-neuronal tissues, such as the kidney, brush border membrane of the intestine and blood brain barrier [4,12]. CT1, which transports creatine, has a ubiquitous expression pattern, often co-localizing with creatine kinase [4].


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GAT1 / SLC6A1 C Show summary » More detailed page go icon to follow link

GAT2 / SLC6A13 C Show summary »

GAT3 / SLC6A11 C Show summary »

BGT1 / SLC6A12 C Show summary »

TauT / SLC6A6 C Show summary »

Target Id 933
Nomenclature TauT
Systematic nomenclature SLC6A6
Previous and unofficial names Sodium- and chloride-dependent taurine transporter | TAUT | taurine/beta-alanine transporter | solute carrier family 6 (neurotransmitter transporter, taurine), member 6 | solute carrier family 6 (neurotransmitter transporter), member 6 | solute carrier family 6 (neurotransmitter transporter
Genes SLC6A6 (Hs), Slc6a6 (Mm), Slc6a6 (Rn)
Ensembl ID ENSG00000131389 (Hs), ENSMUSG00000030096 (Mm), ENSRNOG00000009019 (Rn)
UniProtKB AC P31641 (Hs), O35316 (Mm), P31643 (Rn)
Bioparadigms SLC Tables SLC6A6 (Hs)
Endogenous substrates
GABA [1]
Stoichiometry 2Na+: 1Cl-: 1 taurine

CT1 / SLC6A8 C Show summary »


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.