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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Within the SLC13 family, two groups of transporters may be differentiated on the basis of the substrates transported: NaS1 and NaS2 convey sulphate, while NaC1-3 transport carboxylates. NaS1 and NaS2 transporters are made up of 13 TM domains, with an intracellular N terminus and are electrogenic with physiological roles in the intestine, kidney and placenta. NaC1, NaC2 and NaC3 are made up of 11 TM domains with an intracellular N terminus and are electrogenic, with physiological roles in the kidney and liver.
NaS1 (Na+/sulfate cotransporter / SLC13A1) C Show summary » |
NaC1 (Na+/dicarboxylate cotransporter 1 / SLC13A2) C Show summary » |
NaC3 (Na+/dicarboxylate cotransporter 3 / SLC13A3) C Show summary » |
NaS2 (Na+/sulfate cotransporter / SLC13A4) C Show summary » |
NaC2 (Na+/citrate cotransporter / SLC13A5) C Show summary » |
Database page citation:
SLC13 family of sodium-dependent sulphate/carboxylate transporters. Accessed on 08/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=185.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.