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SLC13 family of sodium-dependent sulphate/carboxylate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Within the SLC13 family, two groups of transporters may be differentiated on the basis of the substrates transported: NaS1 and NaS2 convey sulphate, while NaC1-3 transport carboxylates. NaS1 and NaS2 transporters are made up of 13 TM domains, with an intracellular N terminus and are electrogenic with physiological roles in the intestine, kidney and placenta. NaC1, NaC2 and NaC3 are made up of 11 TM domains with an intracellular N terminus and are electrogenic, with physiological roles in the kidney and liver.

Transporters

977
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NaS1 (Na+/sulfate cotransporter / SLC13A1) C Show summary »


Target Id 977
Nomenclature Na+/sulfate cotransporter
Systematic nomenclature SLC13A1
Common abbreviation NaS1
Previous and unofficial names Renal sodium/sulfate cotransporter | solute carrier family 13 (sodium/sulfate symporters), member 1 | solute carrier family 13 (sodium/sulfate symporter), member 1 | solute carrier family 13 (sodium/sulfate symporters)
Genes SLC13A1 (Hs), Slc13a1 (Mm), Slc13a1 (Rn)
Ensembl ID ENSG00000081800 (Hs), ENSMUSG00000029700 (Mm), ENSRNOG00000008121 (Rn)
UniProtKB AC Q9BZW2 (Hs), Q9JHI4 (Mm), Q07782 (Rn)
Bioparadigms SLC Tables SLC13A1 (Hs)
Endogenous substrates
SeO42-
SO42-
S2O32-
Stoichiometry 3 Na+ : 1 SO42- (in)

NaC1 (Na+/dicarboxylate cotransporter 1 / SLC13A2) C Show summary »

NaC3 (Na+/dicarboxylate cotransporter 3 / SLC13A3) C Show summary »

NaS2 (Na+/sulfate cotransporter / SLC13A4) C Show summary »

NaC2 (Na+/citrate cotransporter / SLC13A5) C Show summary »

Further reading

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References

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How to cite this family page

Database page citation:

SLC13 family of sodium-dependent sulphate/carboxylate transporters. Accessed on 24/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=185.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.