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SLC13 family of sodium-dependent sulphate/carboxylate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Within the SLC13 family, two groups of transporters may be differentiated on the basis of the substrates transported: NaS1 and NaS2 convey sulphate, while NaC1-3 transport carboxylates. NaS1 and NaS2 transporters are made up of 13 TM domains, with an intracellular N terminus and are electrogenic with physiological roles in the intestine, kidney and placenta. NaC1, NaC2 and NaC3 are made up of 11 TM domains with an intracellular N terminus and are electrogenic, with physiological roles in the kidney and liver.

Transporters

979
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NaS1 (Na+/sulfate cotransporter / SLC13A1) C Show summary »

NaC1 (Na+/dicarboxylate cotransporter 1 / SLC13A2) C Show summary »

NaC3 (Na+/dicarboxylate cotransporter 3 / SLC13A3) C Show summary »


Target Id 979
Nomenclature Na+/dicarboxylate cotransporter 3
Systematic nomenclature SLC13A3
Common abbreviation NaC3
Previous and unofficial names NaDC3 | SDCT2 | sodium-dependent high-affinity dicarboxylate transporter 3 | solute carrier family 13 member 3 | solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 | solute carrier family 13 (sodium-dependent dicarboxylate transporter)
Genes SLC13A3 (Hs), Slc13a3 (Mm), Slc13a3 (Rn)
Ensembl ID ENSG00000158296 (Hs), ENSMUSG00000018459 (Mm), ENSRNOG00000019118 (Rn)
UniProtKB AC Q8WWT9 (Hs), Q91Y63 (Mm), Q9Z0Z5 (Rn)
Bioparadigms SLC Tables SLC13A3 (Hs)
Endogenous substrates
citric acid
succinic acid
Stoichiometry Unknown

NaS2 (Na+/sulfate cotransporter / SLC13A4) C Show summary »

NaC2 (Na+/citrate cotransporter / SLC13A5) C Show summary »

Further reading

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References

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How to cite this family page

Database page citation:

SLC13 family of sodium-dependent sulphate/carboxylate transporters. Accessed on 06/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=185.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.