Top ▲

SLC14 family of facilitative urea transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

As a product of protein catabolism, urea is moved around the body and through the kidneys for excretion. Although there is experimental evidence for concentrative urea transporters, these have not been defined at the molecular level. The SLC14 family are facilitative transporters, allowing urea movement down its concentration gradient. Multiple splice variants of these transporters have been identified; for UT-A transporters, in particular, there is evidence for cell-specific expression of these variants with functional impact [1,5]. Topographical modelling suggests that the majority of the variants of SLC14 transporters have 10 TM domains, with a glycosylated extracellular loop at TM5/6, and intracellular C- and N-termini. The UT-A1 splice variant, exceptionally, has 20 TM domains, equivalent to a combination of the UT-A2 and UT-A3 splice variants.

Transporters

982
Click here for help

UT-B (Erythrocyte urea transporter / SLC14A1) C Show summary »


Target Id 982
Nomenclature Erythrocyte urea transporter
Systematic nomenclature SLC14A1
Common abbreviation UT-B
Previous and unofficial names UTB1 | JK | RACH1 | RACH2 | HUT11 | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) | urea transporter 1 | urea transporter B | UrT2 | UT3 | solute carrier family 14 (urea transporter), member 1 | solute carrier family 14 (urea transporter) | solute carrier family 14 member 1
Genes SLC14A1 (Hs), Slc14a1 (Mm), Slc14a1 (Rn)
Ensembl ID ENSG00000141469 (Hs), ENSMUSG00000059336 (Mm), ENSRNOG00000016753 (Rn)
UniProtKB AC Q13336 (Hs), Q8VHL0 (Mm), P97689 (Rn)
Bioparadigms SLC Tables SLC14A1_UT-B1 (Hs), SLC14A1_UT-B2 (Hs)
Endogenous substrates
ammonium carbonate [6]
urea [6]
formamide [6]
Substrates
acrylamide [6]
acetamide [6]
methylurea [6]
Inhibitors
compound 1a [PMID: 23597791] pIC50 ~8.0 [3]
compound 1a [PMID: 23597791] pIC50 7.6 [3] - Mouse
compound 8ay [PMID: 29589443] pIC50 ~5.7 [2] - Rat
Stoichiometry Equilibrative

UT-A (Kidney urea transporter / SLC14A2) C Show summary »

Further reading

Click here for help

Show »

References

Click here for help

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.