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SLC14 family of facilitative urea transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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As a product of protein catabolism, urea is moved around the body and through the kidneys for excretion. Although there is experimental evidence for concentrative urea transporters, these have not been defined at the molecular level. The SLC14 family are facilitative transporters, allowing urea movement down its concentration gradient. Multiple splice variants of these transporters have been identified; for UT-A transporters, in particular, there is evidence for cell-specific expression of these variants with functional impact [1,5]. Topographical modelling suggests that the majority of the variants of SLC14 transporters have 10 TM domains, with a glycosylated extracellular loop at TM5/6, and intracellular C- and N-termini. The UT-A1 splice variant, exceptionally, has 20 TM domains, equivalent to a combination of the UT-A2 and UT-A3 splice variants.


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UT-B (Erythrocyte urea transporter / SLC14A1) C Show summary »

UT-A (Kidney urea transporter / SLC14A2) C Show summary »

Target Id 983
Nomenclature Kidney urea transporter
Systematic nomenclature SLC14A2
Common abbreviation UT-A
Previous and unofficial names UTA1 | HUT2 | UT2 | plasma membrane urea transporter | solute carrier family 14, member 2 | urea transport protein | urea transporter 2 | urea transporter, kidney | UrT1-C | UrT1-D | UT-A1 | UT-A2 | UTA3 | UT-A4 | UT-A3 | UT-A5 | solute carrier family 14 (urea transporter), member 2T | solute carrier family 14 (urea transporter), member 2 | solute carrier family 14 (urea transporter)
Genes SLC14A2 (Hs), Slc14a2 (Mm), Slc14a2 (Rn)
Ensembl ID ENSG00000132874 (Hs), ENSMUSG00000024552 (Mm), ENSRNOG00000061714 (Rn)
UniProtKB AC Q15849 (Hs), Q8R4T9 (Mm), Q62668 (Rn)
Bioparadigms SLC Tables SLC14A2_UT-A1 (Hs), SLC14A2_UT-A2 (Hs), SLC14A2_UT-A3 (Hs), SLC14A2_UT-A4 (Hs), SLC14A2_UT-A5 (Hs), SLC14A2_UT-A6 (Hs)
Endogenous substrates
urea [4]
compound 8ay [PMID: 29589443] pIC50 ~6.8 [2] - Rat
Stoichiometry Equilibrative

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.